Jan and Dan Duncan
Neurological Research Institute


The Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children’s Hospital is advancing the understanding of neurological and neuropsychiatric disorders through basic and translational research to ultimately mitigate the impact of these devastating disorders on human lives.

Our promise is to advance research of neurological and neuropsychiatric disorders and ultimately alleviate the impact of these devastating disorders on human lives.

Our Challenge

More than one billion people—including 300 million children—in the world suffer from some form of neurological disease. In the U.S., there are 50 million children and adults affected, and the number of children is increasing at an alarming pace. To date, more than 600 distinct neurological disorders have been identified. Collaborative, multidisciplinary research is needed to speed basic science discoveries in the laboratory and translation of those discoveries into more effective treatments for patients.

Our Solution

With tremendous support from the local philanthropic community, the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children’s Hospital opened in December 2010. Housed within the 13-story building are laboratories, meeting rooms, vivarium space, and nine shared core facilities that provide faculty with specialized expertise and equipment too costly for individual labs to afford. NRI forums encourage collaboration within the Texas Medical Center, across the country, and around the world, especially between basic scientists and clinicians, ensuring timely distribution of critical information to the broader scientific community. The 25 accomplished faculty and 250 trainees and laboratory personnel who have come together at the NRI—and their discoveries related to disease genes, disease models and new therapeutic approaches—have wildly exceeded even our most ambitious expectations.

The NRI’s overwhelming success in just six years has positioned us to take the next step of translating discoveries made in the laboratory into patient therapies. Philanthropy will help us move in this direction by allowing us to improve and expand the space and add new equipment. In addition, endowment support will secure the future of the NRI and help recruit and retain leading experts in computation, engineering, genetics, neurology, neurophysiology, neuropsychiatry, neuroscience and pathology. Investments like these will ensure that the most important medical breakthroughs in neurological disease research continue to occur at the NRI.

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